Custom Peptides
Cayman Chemical IstradefylIn 10mg
An A2A receptor antagonist (Ki = 2.2 nM in a radioligand binding assay); inhibits haloperidol-induced catalepsy (ED50 = 0.23 mg/kg in rats); alleviates postural defects in a dose-dependent manner without inducing dyskinesias or hyperactivity in an MPTP-induced marmoset model of Parkinson's disease; decreases bradykinesias induced by L-DOPA and improves attentional and working memory deficits in an MPTP-induced macaque model of Parkinson's disease
Cayman Chemical 2 3DImethylethcathInonhyd 10mg
A disubstituted analog of ethcathinone; intended for forensic and research purposes
Cayman Chemical 5-fluoro ABICA 10mg
A homolog of 5-fluoro AB-PINACA that differs by having an indole group in place of the indazole group
Cayman Chemical NacetylSfarnsylLCysteIn 10mg
AFC is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase).{2306,2304} Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.
Cayman Chemical 1 3ChLRophenylpIperazIn 10mg
An analytical reference standard categorized as a piperazine; a metabolite of trazodone; has been found in 3,4-MDMA tablets seized by law enforcement; intended for research and forensic applications
Cayman Chemical EdaglItazon 10mg
A PPARγ agonist; activates PPARγ in a reporter assay using CV-1 cells expressing murine PPARγ2 from 0.1-1 μM; increases [3H]2-deoxyglucose transport in the presence and absence of insulin and increases glycogen synthesis in the presence of insulin in soleus muscle strips isolated from obese rats at 1, 5, and 25 μM
Cayman Chemical MoexIprIlat 10mg
An ACE inhibitor and active metabolite of the prodrug moexipril (IC50 = 2.1 nM); prevents the estrone- or angiotensin II-stimulated proliferation of primary neonatal rat cardiac fibroblasts at 10 nM; reduces mean arterial blood pressure and increases the levels of atrial natriuretic peptide in ovariectomized mice at 50 mg/kg per day
Cayman Chemical 6H05trIfluoroacetate salt 10mg
An allosteric inhibitor of oncogenic K-Ras(G12C); disrupts both switch-I and switch-II, altering the native nucleotide preference to favor GDP over GTP, which impedes binding to Raf
Cayman Chemical 9 Z 11 E 13 ZOctadecatrIe 10mg
An ω-5 long-chain polyunsaturated fatty acid; has been found as a major component in pomegranate seed oil; binds to the AF2 domain of PPARγ (IC50 = 2.5 µM); increases PPARα and PPARγ activity in 3T3-L1 cells in a reporter assay
Cayman Chemical 5FAMLPETGGtrIfluoroACTAt 10mg
A fluorescent peptide; ex/em = 492/518 nm, respectively; has been used for site-specific labeling of target proteins via sortase-catalyzed transpeptidation
Cayman Chemical AM2201 8quInolnyl caramI 10mg
A derivative of cannabimimetic quinolinyl carboxylate and carboxamide-type compounds where 8-quinolinol replaces the naphthalene group of AM2201; intended for forensic and research applications
Cayman Chemical FlurndrenolIde 10mg
A topical corticosteroid with anti-inflammatory actions; activates EGFR with an EC50 value of 23 nM
Cayman Chemical GlucagonhydrochlorIde 10mg
A peptide hormone; produced from proglucagon in pancreatic α cells; stimulates glucose production ex vivo in isolated rat hepatocytes; stimulates glucose output from perfused rat livers via increases in gluconeogenesis and glycogenolysis and decreases in glycolysis; increases plasma glucose levels in rats; secretion is suppressed in response to food intake in normal rats and humans but is maintained or elevated in humans with type 2 diabetes
Cayman Chemical Loxoprofen-SRS 10mg
An NSAID, a COX inhibitor (IC50s = 0.5 and 0.39 for recombinant human COX-1 and COX-2, respectively), and an active metabolite of loxoprofen; intravenous administration inhibits acetic acid-induced writhing, reduces carrageenan-induced mechanical hyperalgesia, and decreases carrageenan-induced paw edema in rats (ED50s = 0.43, 1.28, and 8.01 mg/kg, respectively)
Cayman Chemical 16a-hydroxy Estron 10mg
A hydroxylated metabolite of estrone as well as an interconversion product with estriol; formed by CYP1A1, CYP3A5, CYP3A4, and CYP3A7; binds covalently and persistently activates estrogen receptors; increases cell proliferation and does not suppress TNF-α secretion